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Endocare 120 Caps
$48.00
In stock
Product Details
This product is formulated specifically to maintain healthy
blood pressure levels already within the normal range, by
enhancing endothelial cell and arterial function. Using a
combination of high-dose L-citrulline, quercetin and grape
seed extract, this product delivers full-spectrum support
to help maintain normal inflammatory balance, arterial
elasticity, optimal nitric oxide levels, and blood flow. This
product provides a powerful formula for those seeking to
optimize several mechanisms of cardiovascular health.
Overview
Stress placed on coronary arteries as a result of normal cardiac
function is an expected part of the aging process. This stress
can lead to disruptions in arterial function, proliferation of
vascular smooth muscle, decreases in circulating nitric oxide
(NO) levels, and eventually vasocontraction of key coronary
arteries.1,2 This product provides a blend of targeted nutrients
designed to help dampen this stress by maintaining normal
inflammatory balance, balancing NO levels, maintaining
smooth muscle integrity, and optimizing vasodilation of key
coronary arteries.
L-Citrulline†
L-citrulline is one of three dietary amino acids in the urea cycle
responsible for converting ammonia into urea as well as for the
production of NO, an important cellular signaling molecule. In
this process, L-citrulline is the natural precursor of L-arginine,
the substrate used by endothelial nitric oxide synthase (eNOS) to
produce NO.
As a signaling molecule, NO has been shown to have a very
powerful effect on vasodilation and blood flow.3-5 Because of
this, optimizing circulating NO levels has long been a target
of aerobic and anaerobic athletes. In fact, numerous clinical
trials have been conducted showing that L-citrulline and
L-arginine supplementation have a profound effect on exercise
performance and power output.6-10
The benefits of circulating NO levels stretch far beyond exercise
performance. As a vasodilator, NO improves arterial elasticity,
decreases platelet adhesion, scavenges free radicals, and
prevents oxidation of LDL cholesterol.11-13 Studies show low
levels of NO are associated with endothelial cell dysfunction,
vasoconstriction, and blood flow challenges.13-15 Unfortunately,
supplemental L-arginine has a small, transient effect, with
no long-term benefit on circulating NO levels because liver
metabolism restricts excess arginine from the blood to avoid
long-term physiological consequences.14,16,17
However, recent research shows that supplementing
L-citrulline bypasses liver metabolism, thus making it more
bioavailable in the blood stream and allowing it to significantly
impact circulating NO levels.18 In a direct comparison, a recent
study showed 3,000 mg of L-citrulline supplementation
increased circulating NO levels 1.6-fold higher than 3,200
mg of L-arginine.19 Another direct comparison study showed
L-citrulline supplementation significantly sustained peak
plasma NO levels for upwards of four hours, and NO levels in
the L-arginine group begin to decline at 1.5 hours.20
Quercetin Dihydrate†
A flavonoid found in a variety of botanicals, vegetables and
fruits, quercetin is a potent antioxidant that inhibits inducible
ICAM-1 expression, an important pathway for maintaining
normal inflammatory balance.21 Quercetin has been shown to
support normal inflammatory balance by directly inhibiting the activity of NFkB, similar to turmeric.22 Quercetin is also
known for its ability to improve endothelial cell dysfunction
by maintaining normal inflammatory balance in specific
pathways.23
MegaNatural® BP Grape Seed Extract†
MegaNatural® BP is a premium grape seed extract made in
California from a special seed blend extracted with water from
a variety of white wine grape seeds. Grapes and grape products
contain phenolic compounds found to have health-promoting
properties, particularly in cardiovascular wellness.24 Grape
seed extract has a high concentration of phenolic compounds,
which have been found to support healthy arterial dilation and
blood flow. These polyphenols have been shown to activate
NOS, the enzyme that facilitates NO production.25
A study examining the effects of MegaNatural® BP grape
seed extract in 27 volunteers found that after four weeks
of supplementation with either 150 mg or 300 mg, the
participants were able to maintain healthy blood pressure
levels.26 The participants taking 300 mg also had a significant
reduction in oxidized low-density lipoprotein when compared
to placebo.
Directions
4 capsules per day or as recommended by your health care
professional.
Does Not Contain
Gluten, corn, yeast, artificial colors or flavors.
Cautions
If you are pregnant or nursing, consult your health care
professional before taking this product.
Endocare 120 Caps
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